FELBAMATE PACKAGE INSERT PDF
See package insert. How to take and store Felbamate? Follow your doctor’s directions. Call if you have any questions. Usually, your doctor will tell you to start by. Felbatol is the brand name used in the United States for felbamate. Read the black box warning in the Package Insert to your patient and obtain any necessary . Felbamate, also known as Felbatol, has been approved by the Food and Drug about all potential risks before using this drug and read the package insert.
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Major Estrogens and progestins are both susceptible to drug interactions with hepatic enzyme inducing drugs. It is not known if other risk factors exist, such as dose, concurrent use of other medications, or length of therapy. Moderate Use caution if coadministration of dronabinol with felbamate is necessary, and monitor for a decrease in the efficacy of dronabinol. Moderate Caution is warranted with the coadministration of hydroxychloroquine and antiepileptic drugs, such packsge felbamate.
Bupropion may also interact pharmacokinetically with anticonvulsant drugs that induce hepatic microsomal isoenzyme function. Patients receiving these drugs concurrently felbamare vincristine should be monitored for possible loss of vincristine efficacy.
Moderate Concurrent administration of felbamate and other antiepileptic drugs results in changes in serum concentrations of both felbamate and the antiepileptic drugs. If a breast-feeding baby experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA.
For storage information, see specific product information within the How Supplied section.
Data were analyzed from drugs with adequately designed clinical trials including carbamazepine, felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, tiagabine, topiramate, valproate, and packagw. However, this is considered to be a class effect.
Felbamate should be discontinued if signs and symptoms of hematologic abnormalities or any sign of bone marrow depression occurs. Ffelbamate Avoid coadministration of isavuconazonium with felbamate. If felbamate must be used, consider reducing use of other CNS-active medications that increase the risk of falls and fractures and implement other strategies to reduce fall risk.
Felbamate is contraindicated in patients with a felbamate or carbamate hypersensitivity. Clinical signs and symptoms may include infection, bleeding, or anemia.
Regular ingestion of ethanol followed by abrupt discontinuation can provoke seizures. We insett not record any personal information entered above. Moderate Felbamate has been shown to increase valproic acid serum concentrations, however the magnitude of this effect varies.
Minor Bone marrow suppression is associated with guanidine therapy. High or toxic serum concentrations should become a consideration for dosage adjustments.
Felbamate may cause hepatotoxicity and hepatic failure. Major Coadministration of felbamate with darunavir is not recommended. The serious toxicities of felbamate, such as aplastic anemia, would also warrant that felbamate be used during pregnancy only if clearly needed. Major Coadministration of felbamate with atazanavir is not recommended.
According to the OBRA guidelines, some anticonvulsants may be used to treat disorders other than seizures e. Minor Use caution if coadministration of maraviroc with felbamate is necessary, due to a possible decrease in maraviroc exposure. Therefore, it is recommended that felbamate only be used in patients with severe epilepsy for which the benefits of the drug outweigh the risks of hepatic failure and other toxicities.
Agents inaert induce CYP3A4 may increase the metabolism of vincristine and decrease the efficacy of drug, including felbamate. Major Avoid concurrent use of felbamate with bedaquiline.
Felbatol (felbamate) dose, indications, adverse effects, interactions from
Moderate Caution is advised when administering terbinafine with felbamate. Therefore, use of praziquantel with felbamate, a CYP3A4 inducer, should be done with caution as concomitant use may felbamste therapeutically ineffective concentrations of praziquantel.
Dosage adjustment of methsuximide may be required. Minor The metabolism of dapsone may be accelerated when administered concurrently with felbamate, a known inducer of CYP3A4. If these drugs must be administered together, closely monitor for a reduction in dapsone efficacy and signs of hemolytic anemia. An alternate or additional form of contraception should be used during concomitant treatment. Theoretically, CYP2C19 inhibitors, such as felbamate, may result in elevated voriconazole serum concentrations when coadministered.
Moderate Consistent with the pharmacology of molindone, additive effects may occur with other CNS active drugs such as anticonvulsants.
Moderate Caution is advised when administering elbasvir; grazoprevir with felbamate. Oral dosage-Conversion to Monotherapy. Coadministration is expected to decrease the plasma concentration of dapsone oackage increase the formation of dapsone hydroxylamine a metabolite associated with hemolysis. There were 4 completed suicides among patients in drug treatment groups versus none in the placebo groups.
Felbamate is classified as FDA pregnancy risk category C. Additionally, patients taking non-oral combination contraceptives or estrogens or progestins for hormone replacement therapy may also experience reduced clinical efficacy; dosage adjustments may be necessary.