Water Deprivation Protocol – Biochemistry Departments City Hospital. Indications . Investigation of suspected cranial or nephrogenic diabetes insipidus and. A fluid or water deprivation test is a medical test which can be used to determine whether the patient has diabetes insipidus as opposed to other causes of. The differential diagnosis of diabetes insipidus (DI) is often challenging but essential, 1 October , Pages –, arginine vasopressin determination over the indirect water deprivation test. diagnostic specificity and simplification of the differential diagnostic protocol in DI.

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Endocrine Abstracts

The physiological and pathophysiological functions watter renal and extrarenal vasopressin V2 receptors. The removal of aggravating factors e. This article has been cited by other articles in PMC. Although spontaneous remission of gestational DI normally occurs within 2 to 3 wk postpartum, diagnostic evaluation for possible underlying disorders should be considered Table 1.

Polyuria is generally defined as urine output exceeding 3 liters per day in adults. New formulation of desmopressin: Polydipsia and water intoxication diabtes psychiatric patients: Open in a separate window. A new tool, the Nagasaki DI Questionnaire, included 10 questions directly related to CDI symptoms and two questions about the consistency of the effect of and the patient’s satisfaction with desmopressin has recently been tested. If compared with the normal physiological relationship between plasma AVP ort serum osmolality Fig.


Another critical point refers to the area of normality describing the physiological behavior of plasma AVP release in relation to the corresponding serum osmolality. Diabetes insipidus — Diagnosis and management. Can Med Assoc J.

Differentiation of polyuric states by measurement of responses to changes in plasma osmolality induced by hypertonic saline infusions. Indian J Med Sci.

There was a significant antidiuretic activity even in patients who were water-loaded. Plasma vasopressin response to hypertonic saline infusion to assess posterior pituitary function. Differential diagnosis between diabetes insipidus and compulsive polydipsia.

International Scholarly Research Notices

The water restriction test helps to determine the cause of polyuria. Predictors and incidence of central diabetes insipidus after endoscopic pituitary surgery.

A challenging diagnosis with new drug therapies. Normal response to nicotine and pitressin, but no response to NaCl in 3 subjects with posterior pituitary damage; abnormal response to nicotine and normal response to NaCl in patients with PP. Conflicts of interest Dr.

Orally disintegrating tablet The ODT formulation of desmopressin was launched in for the treatment of nocturnal enuresis. But for diagnostic purposes, these nonosmotic tests of neurohypophyseal function do not provide advantages over the osmotic stimuli because they are difficult to control or quantitate and generally cause a markedly variable AVP response 90 Moreover, insipidks clinical use of copeptin levels as a surrogate of AVP secretion during osmotic stimulation still requires a larger database of normal and abnormal responses, and the reported diagnostic cutoff values that were determined in a post hoc analysis still need to be validated prospectively.


Fenske W, Allolio B. Quality of life in the patients with central diabetes insipidus assessed by Nagasaki Diabetes Insipidus Questionnaire. Importantly, patients can still demonstrate a physiological antidiuretic response to waer 35 and other non-osmotic stimuli of AVP release 36 Novel mutations associated with nephrogenic diabetes insipidus.

In recent years, cMRI has emerged as another useful addition to the biochemical tests in the diagnosis of DI.

How to do a water deprivation test: interpretation of results | SFEBES

Cyclic adenosine monophosphate, V2R: Clofibrate-induced myopathy in patients with diabetes insipidus. Patients should stop drinking.

The long-term use of oral desmopressin has been evaluated. This leads to polyuria, polydipsia with hyposthenuria, causing dehydration and hypernatremia if the patient is deprived of water [ 2 ]. Urine osmolality is measured 30—60 min after this.