Correspondence from The New England Journal of Medicine — Cellulitis. To the Editor: In their article on the Prophylactic Antibiotics for the Treatment of Cellulitis at Home I (PATCH I) trial, Thomas et al. (May 2 issue)1 report that the. In a recent retrospective study of patients who were hospitalized with presumed cellulitis, dermatologists concluded that roughly 30% of.

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Treat tinea pedis or candida infection with topical terbenifine or miconazole respectively. Are they suitable for compression? We compared prophylactic low-dose penicillin with placebo for the prevention of recurrent cellulitis.

Penicillin to prevent recurrent leg cellulitis.

Bilateral cellulitis is uncommon. A total of patients were recruited. Participants were followed for up to 3 years. Refer for specialist opinion if severe infection Is it cellulitis?

Amiodarone and drugs which prolong the QT interval can interact with many antibiotics. Statins can interact with some cellulitid and increase the risk of rhabdomyolysis. Doses are oral and for adults unless otherwise stated.


Penicillin to prevent recurrent leg cellulitis.

We conducted a double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland.

Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only.

Comment in N Engl J Med. Leg Ulcers and recurrent cellulitis. Prophalactic antibiotics for the prevention of cellulitis erysipelas of the leg: Cellultiis do not improve celluliti unless active infection. Skip to main content. N Engl J Med. The primary outcome was the time to a first recurrence.

Review antibiotics after culture results. Please refer to our Drug Interactions Table for further information. Many antibiotics increase the risk of bleeding with anticoagulants.

Colonisation is likely in leg ulcers. The median time to a first recurrence of cellulitis was days in the penicillin group and days in the placebo group. Baseline characteristics were similar in the two groups.


Leg Ulcers and recurrent cellulitis –

Randomization was performed according to a computer-generated code, and study medications penicillin [ mg ce,lulitis a day] or placebo for 12 months were dispensed by a central pharmacy. Is it chronic changes of venous stasis and chronic ulceration? Penecillin to prevent leg cellulitis NEJM ; Overall, participants in the penicillin group had fewer repeat episodes than those in the placebo group vs.

In patients with recurrent cellulitis of the leg, penicillin was effective in preventing subsequent attacks during prophylaxis, but the protective effect diminished progressively celluliits drug therapy was stopped.

Comments from Expert Advisory Committee Antibiotics do not improve healing unless active infection. Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue.