, Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B Hille. The Journal of general physiology 69 (4), Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na + and K + channels of axons. Ionic Channels of Excitable Membranes by Bertil Hille (). $ Hardcover. Books by Bertil Hille. Showing 3 Results Books: Advanced Search.

Author: Vudogore Gardakree
Country: Germany
Language: English (Spanish)
Genre: Life
Published (Last): 13 September 2009
Pages: 451
PDF File Size: 4.18 Mb
ePub File Size: 3.86 Mb
ISBN: 119-1-42477-752-9
Downloads: 95711
Price: Free* [*Free Regsitration Required]
Uploader: Telar

And he was a very good friend And also I think that it is not a very popular subject.

Bertil Hille

I had decided that, again, my mind was just not the right sort for medicine. He said that you couldn’t write or talk about what you did when you were younger without actually going back and reading what you wrote down at the very same time, because you would always make yourself look better. So I did those on the weekends, too. I learned a very great deal from Clara, including a positive attitude that, uh—I tend to be somewhat skeptical.

Next, he went on to Duke and then Rochester before arriving to stay at the University of Pennsylvania. I never applied anywhere. Edgar Douglas Adrian Cambridge.

Ionic channels of excitable membranes: Bertil Hille: : Books

The Journal of general physiology 50 5, That’s our second trip to Nepal. In all cases, a drug can neither get into nor out of a cell unless the potassium channel gates are open. My mother was also, although she wasn’t a scientist by training, she was beertil excellent in knowing causality and thinking about the laws of physics and making things follow from each other and being interested in betil kinds of science.

People Participating Faculty Bertil Hille. Bertil Hille pioneered the concept of ion channels as membrane proteins forming gated aqueous pores with Clay Armstrong.

Through a series of elegant experiments, they showed that the pore loop defines the essence of a potassium channel by forming its selectivity filter, conferring the ability to accept potassium and exclude sodium.


An important set of classes that I had taken at Rockefeller was from Dan Koshland who was vertil. It was very exciting and very formative for me.

Help us improve our Author Pages by updating your bibliography and submitting a new or current image and biography. Somehow people manage to find some sealing wax and thread and make it work somehow. And oddly enough, it’s a corner of the world that I thought no one would ever know about, and I discovered that, in fact, Chris Miller had family connections in Hugo, Oklahoma, which is where my maternal grandparents grew up.

And well it all seemed to fit quite well with the general idea that the pore had a wide inner mouth and then narrowed so that the TEA derivative couldn’t work its way through, since it was not possible for it to lose its covalently attached hilpe.

So the first experiment to try and see if sodium inactivation had similarities was to see if one could see a lag in inactivation that was consistent with the idea that the channel had to open before it could inactivate. As sodium and potassium channels? It is considered the scholarly bible of ion channels and is one of the more cited publications in the scientific literature.

But to do experiments you have to have a lot of time. And that turned out to be pretty hard.

Write a customer review. But then he was telling me that it was too hard to ever do again. And we subsequently found that, in fact, it immobilized about two-thirds of the charge. Earlier he had used physiology and molecular biology to demonstrate that a potassium channel consists of four subunits and to identify the amino acids that line the channel’s outer vestibule and pore.

Bronk called the Rockefeller a “community of scholars” and said that we were part of the community of scholars, so at once we were no longer students, we were just part of the community of scholars. But no one had ever done voltage clamp with a digital computer at that time. And Eduardo Rojas was in England at the time, and so he communicated some of this fervor to Pancho and to me.


Instead of the other half of the world, it was just something we had lived in and knew how they thought in a way.

Similar authors to follow

I’ve forgotten the details, but it was pretty much showing that really a vertebrate nerve functioned in the same way as the squid axon. B, ComiXology Thousands of Digital Comics. Yeah, that was spectacular. So I guess an important part of the ball and chain mechanism was the idea that the channel had to open before the ball could go in and get stuck in the throat of the channel. Well, he was actually at the medical school at that time.

English Choose a language for shopping. I met Stephen Hladkey in Cambridge when I was a postdoc, and they were just starting those experiments.

Well, I was in the laboratory of Alex Mauro, where he and Alan Finkelstein had been writing papers about electrodiffusion. So I thought you just had to take the water off because otherwise you couldn’t see what was in there.

It seemed that the channel had to be the way. Proceedings of the National Academy of Sciences 89 9, Alan Lloyd Hodgkin Cambridge. He is particularly well known for his research and expertise on cell signalling by ion channels. For one thing, it was, of course, a complete change of surroundings.